Hello.
I am Dr. Kim Dong-young, Director of Cleor Clinic Hongdae Branch.
Have you ever felt that even after applying your skincare products, your skin's condition doesn't improve from within, and fine lines are gradually setting in?
"I've tried moisturizing lines and vitamin ampoules, but as time goes by, it feels like my skin's natural resilience is weakening."
Skin resilience depends on how well the fibroblasts in the dermis layer produce collagen and elastin.
As we age or accumulate damage from UV rays and stress, fibroblast activity gradually declines, and the foundation of the dermis layer loosens, creating an environment where recovery from even minor irritation feels slow.
Just as plants grow well when the soil is healthy, the Hongdae Rejuran Healer approach focuses on sending signals to cultivate the soil of the dermis layer itself.
Today, I will explain what the Hongdae Rejuran Healer procedure is, how the various Rejuran lines are categorized, and the clinical results regarding pain reduction with the HB line.
What is Hongdae Rejuran Healer?
👉 Hongdae Rejuran Healer is a skin booster procedure that uses Rejuran Healer from the Korean company PharmaResearch. It involves injecting PN (polynucleotide), purified from salmon testes DNA, directly into the dermis layer to stimulate fibroblast activity and create an environment for self-regeneration.
Rejuran Healer is the original product in the Rejuran line.
PN is known to have a structure more than 95% similar to human DNA, so it has high biocompatibility. Once it reaches the dermis layer, it works by stimulating collagen remodeling and self-regeneration signals.
The reason it is commonly called "salmon injection" is that PN is a component extracted from salmon testes DNA.
The biggest difference from cosmetic care, which only supplies moisture to the epidermis, is that it acts on the foundation of the dermis layer itself.
Technical Features of Hongdae Rejuran Healer
👉 Hongdae Rejuran Healer is a procedure with four key features: PN component action, fibroblast stimulation, direct injection into the dermis, and creation of a self-regeneration environment.
PN (Polynucleotide) Component
PN is a nucleic acid component purified from salmon testes DNA. It is known to have high biocompatibility because it is more than 95% similar to human DNA.
Since it is a pure nucleic acid with proteins removed, it can often be used even by those with salmon allergies. However, as hypersensitive reactions can rarely occur, we check for allergy history during the pre-procedure consultation.
Stimulation of Fibroblast Activity
It is reported that when PN reaches the dermis layer, it stimulates the activity of fibroblasts that create collagen and elastin.
Because it works by sending signals to the skin's own regeneration system, changes tend to settle in more effectively when the procedure is repeated rather than done just once.
Direct Injection into the Dermis Layer
This method involves multiple injections of tiny amounts into the dermis layer, approximately 70 to 80 times per area.
Because it is a structure that delivers PN directly to a depth that is difficult to reach with surface application, it is operated as a medical device procedure.
Creation of a Self-Regeneration Environment
PN is not collagen supplied from the outside, but a method that stimulates the environment where the skin can produce its own collagen, so it is known as a procedure where gradual and natural changes take place.
Effects and Advantages of Hongdae Rejuran Healer
👉 The key advantages of Hongdae Rejuran Healer can be summarized into three points: stimulation of self-regeneration in the dermis, simultaneous care for the entire face, and gradual, natural changes.
First, it cultivates the foundation of the dermis layer again.
Unlike surface moisturizing care, it is reported to stimulate fibroblast activity in the dermis layer, paving the way for collagen and elastin production.
Next, it allows for simultaneous care of the entire face.
Because it acts on the self-regeneration environment of the entire face rather than just specific areas, it is known to help improve fine lines, elasticity, and skin texture together.
Finally, the changes are gradual and natural.
It is not about immediate volume changes or artificial lifting, but rather changes that settle in calmly from within as collagen fills in, so many say it is a procedure where it is "hard to tell you've had anything done."
Hongdae Rejuran Healer Lineup
👉 At the Hongdae branch, we operate lines categorized by area and pain tolerance, centered on Rejuran Healer, allowing you to choose according to the area, from the face to the eye area, lips, neck, and scars.
Full Face Line
If Rejuran Healer is the PN-only line, Rejuran HB is a line formulated with hyaluronic acid and the local anesthetic lidocaine.
The inclusion of lidocaine is the key difference. In a clinical trial conducted at Seoul National University Bundang Hospital, 81% of subjects experienced pain relief, and an average of 53% pain reduction was reported compared to the existing product.
Rejuran Healer is known to have some pain burden as it involves 70–80 micro-injections, so the HB line is operated as an option to reduce this burden.
Area-Specific Lines
Rejuran S is a line dedicated to scar regeneration with higher viscosity than the original Healer.
It acts directly on atrophic scars where the skin is sunken, and is used to promote tissue regeneration and volume recovery.
We will determine the line that suits your area of concern and pain tolerance during the pre-procedure consultation.
Who is Hongdae Rejuran Healer suitable for?
Those concerned about fine lines across the face and declining skin resilience
Those who feel that surface moisturizing care provides weak results
Those who want to strengthen the foundation inside the skin
Those who want to utilize self-regeneration without incisions or strong procedures
Those who want to explore lines with less pain burden (HB)
Side Effects and Things to Know Beforehand for Hongdae Rejuran Healer
👉 Hongdae Rejuran Healer is a procedure where changes stabilize when performed cumulatively 3 to 4 times or more at 2–4 week intervals, rather than being completed in one session.
Immediately after the procedure, fine embossing marks, light swelling, bruising, and stinging may accompany the injection sites.
Embossing usually absorbs naturally within 1–2 days, and if bruising occurs, it is reported to subside within 4–7 days.
Rejuran Healer is a PN-only line, so there is some pain burden during the procedure.
Due to the nature of the procedure involving 70–80 micro-injections, for those sensitive to pain, the lidocaine-containing HB line is naturally recommended, so we discuss pain burden during the pre-procedure consultation.
Although PN is a component similar to human DNA, hypersensitive reactions are rarely reported, so please let us know if you have a history of allergies.
Please inform us in advance as the procedure may be restricted in the following cases:
If you are pregnant or breastfeeding
If there is active inflammation, herpes, or infection at the treatment site
If you are regularly taking medication that increases bleeding tendency
If you have been diagnosed with an autoimmune disease
If you have a keloid tendency or are prone to scarring
⚠️ Precautions Before and After Hongdae Rejuran Healer Procedure
👉 For Hongdae Rejuran Healer, management at each stage before and after the procedure affects recovery and the feeling of results.
❓ Frequently Asked Questions (FAQ)
Q. How is Hongdae Rejuran Healer different from Rejuran HB?
Rejuran Healer is a PN-only line, and Rejuran HB is a line formulated with PN, hyaluronic acid, and the local anesthetic lidocaine.
Since the active ingredients are the same, the basic effects are identical, but HB is operated in a way that reduces pain burden and adds a "water-glow" effect.
In the clinical trial at Seoul National University Bundang Hospital, 81% of subjects experienced pain relief, and an average of 53% pain reduction was reported.
Q. How much pain is involved with Hongdae Rejuran Healer?
The Healer line is known to have some pain burden as it involves 70–80 micro-injections in one area.
Applying numbing cream before the procedure is standard, and for those sensitive to pain, the lidocaine-containing HB line is naturally recommended.
Q. How many sessions of Hongdae Rejuran Healer are needed to see changes?
Although it depends on the skin condition, generally, changes stabilize when performed cumulatively 3 to 4 times or more at 2–4 week intervals.
Sessions are recommended because the dermis layer environment strengthens as they accumulate.
Q. How long do the effects of Hongdae Rejuran Healer last?
It is reported to last for about 6–12 months after 3–4 cumulative sessions.
In many cases, additional procedures are decided based on the condition afterward, and there are individual differences.
Q. What should I do if I get bruises after receiving Hongdae Rejuran Healer?
Because it is a multi-injection procedure, light bruising may occur.
Most of it absorbs naturally within 4–7 days, and it is to the extent that you can cover it with light concealer and go about your daily life.
Q. Can I receive Hongdae Rejuran Healer on my lips or scar areas?
Area-specific lines are operated together.
For lips, the "Lipjuran" line using Rejuran HB is used to consider pain burden; for sunken scars, the Rejuran S line with increased viscosity is used; and for the eye area, the Rejuran I line with lowered viscosity is used according to the area.
We will determine the line that fits your area of concern during the pre-procedure consultation.
Q. Can I wear makeup immediately after receiving Hongdae Rejuran Healer?
Since embossing marks and irritation remain on the day of the procedure, light makeup is fine, but full makeup is recommended from the next day.
Skin resilience begins with fibroblast activity in the dermis layer and the environment for collagen production.
This is also why the approach of cultivating the foundation of the dermis layer itself has become established when changes at a depth difficult to reach with surface care are needed.
Hongdae Rejuran Healer is a skin booster that uses Rejuran Healer from the Korean company PharmaResearch to inject PN purified from salmon DNA directly into the dermis layer.
At the Hongdae branch, we operate with a structure where you can choose according to the area, including the Healer, the pain-reduced HB line, the eye-specific I line, lip-specific Lipjuran, neck wrinkle line, and the Rejuran S line for sunken scars.
We will personally confirm the line configuration that suits your area of concern and pain tolerance during the consultation.
If you are concerned about fine lines across your face and skin resilience, please feel free to visit Cleor Clinic Hongdae Branch.
Even before deciding on the procedure, we will provide detailed guidance on your skin condition and suitable care directions through a pre-procedure consultation.
※ This content is for general information purposes only, and results may vary by individual.
Please decide on accurate diagnosis and whether to proceed with the procedure through consultation with a specialist.
자가면역 질환을 진단받은 경우
켈로이드 체질이거나 흉터가 잘 남는 편인 경우
⚠️ 홍대 리쥬란 힐러 시술 전후 주의사항
👉 홍대 리쥬란 힐러는 시술 전과 후 모두 시점별 관리가 회복과 결과 체감에 영향을 줍니다.
❓ 자주 묻는 질문 (FAQ)
Q. 홍대 리쥬란 힐러와 리쥬란 HB는 어떻게 다른가요?
리쥬란 힐러는 PN 단독 라인이고,
리쥬란 HB는 PN에 히알루론산과
국소 마취제 리도카인이 함께 배합된 라인이에요.
작용 성분이 같아 기본 효과는 동일하지만,
HB는 통증 부담을 줄이고 물광 효과를 추가하는 방향으로 운영됩니다.
분당서울대병원 임상에서 피험자 81%가 통증 완화를 경험하고
기존 대비 평균 53% 통증 감소가 보고된 라인이에요.
Q. 홍대 리쥬란 힐러 통증은 어느 정도인가요?
힐러 라인은 한 부위에 70~80회의 미세 주사가 진행되는 시술이라
통증 부담이 있는 편으로 알려져 있어요.
시술 전 마취 크림 도포가 일반적이고,
통증에 민감한 분이라면 리도카인이 함유된 HB 라인이 자연스럽게 권해지는 편입니다.
Q. 홍대 리쥬란 힐러는 몇 회 받아야 변화가 보이나요?
피부 상태에 따라 다르지만 일반적으로
2~4주 간격으로 3~4회 이상 누적 진행할 때 변화가 안정되는 편이에요.
누적될수록 진피층 환경이 다져지는 흐름이라 회차가 권해집니다.
Q. 홍대 리쥬란 힐러 효과는 얼마나 유지되나요?
3~4회 누적 진행 후 약 6~12개월 정도 유지되는 것으로 보고됩니다.
이후 컨디션을 보며 추가 시술 여부를 결정하는 경우가 많고
개인차가 있습니다.
Q. 홍대 리쥬란 힐러 받고 멍이 들면 어떻게 하나요?
다중 주사 시술이라 가벼운 멍이 들 수 있어요.
대부분 4~7일 안에 자연 흡수되는 편이고
가벼운 컨실러로 가리고 일상을 보낼 수 있는 정도입니다.
Q. 홍대 리쥬란 힐러 입술이나 흉터 부위에도 받을 수 있나요?
부위별 전용 라인이 함께 운영돼요.
입술은 통증 부담을 고려해 리쥬란 HB를 사용하는 립쥬란 라인,
패인 흉터에는 점성이 강화된 리쥬란 S 라인,
눈가에는 점도를 낮춘 리쥬란 아이 라인이 부위에 맞춰 운영됩니다.
본인 부위 고민에 맞는 라인은 사전 진료에서 정리합니다.
Q. 홍대 리쥬란 힐러 받고 바로 메이크업이 가능한가요?
시술 당일은 엠보싱 자국과 자극이 남아 있어
가벼운 색조 정도로만 하시고 본격 메이크업은 다음 날부터가 권해져요.
피부 회복력은 진피층 섬유아세포 활동과 콜라겐 생성 환경에서 시작됩니다.
표면 케어만으로는 닿기 어려운 깊이의 변화가 필요할 때
진피층 토대 자체를 다시 가꾸는 방향이 자리 잡은 이유이기도 해요.
홍대 리쥬란 힐러는 한국 파마리서치사의 리쥬란 힐러를 사용해
연어 DNA에서 정제한 PN을 진피층에 직접 주입하는 스킨부스터예요.
홍대점에서는 힐러를 중심으로 통증을 줄인 HB 라인,
눈가 전용 아이 라인, 입술 전용 립쥬란, 목주름 라인,
패인 흉터 전용 리쥬란 S 라인까지 부위에 맞춰 선택할 수 있는 구조로 함께 운영하고 있습니다.
본인 부위 고민과 통증 부담에 어울리는 라인 구성은
상담 시 직접 확인해 드립니다.
얼굴 전반 잔주름과 피부 회복력이 신경 쓰인다면
클레오르의원 홍대점으로 부담 없이 방문해 주세요.
시술 결정 전이라도 사전 진료를 통해 본인 피부 상태와
어울리는 케어 방향을 자세히 안내해 드리겠습니다.
※ 본 내용은 일반적인 정보 제공을 위한 글이며, 개인에 따라 결과는 달라질 수 있습니다.
정확한 진단과 시술 여부는 전문의 상담을 통해 결정하시기 바랍니다.